Skip to main content


Contact Information

April - 2011 Edition: Some information may be out of date.

Featured Company: St. Renatus

A Fort Collins start-up company will soon provide some needed relief to dental patients. In the not-so-distant future, you may be the recipient of needle-free anesthesia that doesn’t numb your lips or cheeks, but is as effective at blocking pain as the traditional needle delivery.

FDA Trials

St. Renatus recently completed Adult Phase 2 trials with the U.S. Food and Drug Administration (FDA) review and will begin Phase 3 trials shortly. The path to an approved drug by the FDA is complex and takes years or decades to achieve. St. Renatus is the exception for a variety of reasons, mainly because the base of its anesthesia is a re-characterized, existing medication. In its new molecular form which allows for nasal spray delivery method, it is moving swiftly through the FDA review process. 

The road to success in FDA trials is narrow—out of 10,000 applicants, only about five make it to Phase 3 clinical trials. The application for the nasal spray is for the upper jaw only at this time. There is hope its use can be expanded to effect the lower jaw as well.

Operational Overview

St. Renatus is operating at a global level, with manufactures in Europe helping to provide some of the equipment and materials for the nasal spray, and a board of directors that is similar to an all-star athletic team. One of the co-founders, Dr. Mark Kollar, DDS, lives in Fort Collins and has attracted the interest of local and national specialist to fill positions on the Board of Directors and Scientific Advisory Board.

Location, Location, Location

While a company like St. Renatus can locate anywhere, it’s Fort Collins’ way of life that keeps the employees and executive team in town—proximity to the Rocky Mountains, nearly 300 days of sunshine a year; and community amenities that are hard to beat. Fort Collins provides the perfect place to grow a promising bioscience company.

Interesting Information

And since the name of the company is unique and has people scratching their heads for the meaning, here’s the story: Renatus is a Latin term for new beginnings, and St. Renatus is the patron saint of anesthesia.

To learn more about the company, its drug product and mission to knockout fear and loathing in the dentist office, visit